Juniper Publishers-Nasal Delivery of Proteins and Peptides
Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Nasal Delivery of Proteins and Peptides Authored by June Shao Introduction Recent years have shown that nasal route can be a potential route for the systemic delivery of protein/peptide drugs as it has a considerably large absorption area (150cm2) which is highly vascularized and has permeability similar to or higher than the small intestinal mucosa. Nasal delivery of protein/peptide drugs also offers other benefits such as ease of administration, noninvasive administration, rapid onset of action, and the avoidance of gastrointestinal degradation and hepatic first-pass effects [ 1 ]. Nasal route can be utilized to enhance the delivery of drugs to the brain as nose to brain delivery bypasses the blood-brain barrier [ 2 ]. However, nasal delivery also suffers from several limitations such as low membrane permeability to hydrophilic molecules (especially when the molecular weigh...