Formulation and Evaluation of Chronomodulated Drug Delivery of Montelukast Sodium--Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES An oral press coated tablet containing Montelukast sodium was formulated with an outer barrier layer of different compositions of hydrophobic polymer eythyl cellulose and hydrophilic polymer hydroxyl propyl methyl cellulose. This press coated tablet was prepared by using direct compression and wet granulation methods in order to achieve the predetermined lag time. Keywords: Pulsatile drug delivery systems (PDDS); Nocturnal asthma(NA); Chronopharmacology; Circadium Rhythms; Burst release; Lag time Abbreviations: EC: Ethyl Cellulose; HPMC: Hydroxy Propyl Methyl Cellulose; FTIR: Fourier Transform Infra Red; SLS: Sodium Lauryl Sulphate; IR: Immediate Release; ChrDDS: Chrono Modulated Drug Delivery Systems; PCT: Press Coated Tablets Introduction Controlled drug delivery systems [1] have acquired a centre stage in the area of pharmaceutical R &D sector. Such systems offe...