Juniper Publishers: A Critical Analysis of Polymersome Therapeutics: F...

Juniper Publishers: A Critical Analysis of Polymersome Therapeutics: F...: Current Trends in Biomedical Engineering & Biosciences Juniper Publishers Authored by  Adriano Marim de Oliveira * Introdu...

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JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Introduction Ascites is the most common of the three major complications of cirrhosis; the other complications are hepatic encephalopathy and variceal hemorrhage [ 1 ]. Approximately 50% of patients with "compensated" cirrhosis develop ascites during 10 years of observation [ 1 ]. Ascites is the most common complication of cirrhosis that leads to hospital admission [ 2 ]. Development of fluid retention in the setting of cirrhosis is an important landmark in the natural history of chronic liver disease: approximately 15% of patients with ascites succumb in 1 year and 44% succumb in 5 years [ 3 ]. Many patients are referred for liver transplantation after development of ascites. Refractory ascites develops in approximately 5-10% of all cases of cirrhosis- related ascites and carries a high mortality rate [ 4 ]. The available therapies for patients with refractory ascites are re...
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