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Etilefrine Could Improve Response to Standard Medical Therapy in Chronic Hepatitis C Egyptian Patients with Cirrhotic Refractory Ascites: A Randomized Pilot Study-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Ascites is a frequent complication of cirrhosis that accounts for over 75% of episodes of ascites. Patients with cirrhotic ascites have marked splanchnic vasodilation and arterial hypotension with subsequent activation of vasoconstrictive and anti-natriuretic mechanisms. One of the most serious complications in cirrhotic patients with ascites is the occurrence of refractoriness that is the inability to resolve ascites by the standard medical treatment. The aim of this study is to evaluate the effects of etilefrine on systemic hemodynamics, renal function and control of ascites in chronic hepatitis C (CHC) patients with cirrhotic refractory ascites receiving standard medical treatment (SMT) with low sodium diet and maximal diuretic doses of 160mg/day of furosemide and 400mg/day of spironolactone. Methods: A total of 50 CHC patients with cirrhotic refractory ascites were prospe...
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Comparison of Morphological Analysis of RBC through Peripheral Smear and Automated Method-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Aim: To compare the morphology of red blood cells by peripheral smear and automated method. Objective: Comparison of morphology of red blood cells by using peripheral smear and automated method. Background: Counting of red blood cells (RBC) in blood cell images is very important to detect as well as to follow the process of treatment of many diseases like anaemia, leukaemia etc. However, locating, identifying and counting of -red blood cells manually are tedious and timeconsuming that could be simplified by means of automatic analysis. Reason: To know which is the most effective method of analysing morphology of RBC. Keywords: Red blood cells; Observers; Automated method Introduction Red blood cells (RBCs), also known as erythrocytes, are the most common type of blood cells in our body and it is the principal means of delivering ...
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Formulation and Evaluation of Solid Dispersion of Glimepiride into Sustained Release-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers. Keywords: Solid dispersion, Diabetes mellitus, Sustained drug release Abbreviations: PVP: Poly Vinyl Pyrrolidone; HPMC: Hydroxy Propyl Methyl Cellulose; FTIR: Fourier Transform Infra Red; MCC: Micro Crystalline Cellulose Introduction The objective of sustained release [1] dosage form i...
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