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Genotoxicity: Mechanisms, Testing Guidelines and Methods

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  JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Authored by  Rajendra SV Abstract Genotoxicity is one of the major causes for cancer. Genotoxins are agents that can cause the damage of DNA or chromosomal structure thereby causing mutations. It can be chemical or radiation. This damage in the somatic cells will lead to various diseases ranging to cancer whereas the damage to the germ cell will lead to heritable diseases. Better identification and understanding of genotoxins would enable us to prevent the potential damage that can be caused by these genotoxic agents. In this article we discuss about the basic of genotoxicity and the importance of genotoxic studies. Keywords:  Genotoxins, Mutagens, DNA Damage, Chromosomal mutation, Testing guidelines. Go to Introduction Genotoxicity is a word used in genetics that describes the possession of substance that has destructive effect on the genetic material of the cell (DNA, RNA) thus aff...
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Comparison of Morphological Analysis of RBC through Peripheral Smear and Automated Method-Juniper Publishers

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Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences I ntroduction Red blood cells (RBCs), also known as erythrocytes, are the most common type of blood cells in our body and it is the principal means of delivering oxygen to the body tissues.The red blood cells are typically biconcave disks: flat and depressed in the centre, with a dumbbell-shaped cross section, and a rim on the edge with the torus shapeddisk [ 1 ]. Red blood cells in mammals are unique amongst vertebrates as they do not have nuclei when mature.Anaemia is the lack of red blood cells and/ or haemoglobin. This results in a reduced ability of blood to transfer oxygen to the tissues [ 2 ]. Normal, mature RBCs are biconcave, disc-shaped, a nuclear cells measuring approximately 7-8 microns in diameter on a peripheral blood smear with an internal volume (MCV) of 80-100 femto liters (fL). The term used to describe RBCs of normal size is "normocytic". Anaemia is...
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