Cytotoxic, Antimicrobial and Anti-oxidant Screening of Psidium Guajava Leaves Grown in Oman-Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences


Authored by Afaf M Weli

 Psidium guajava (guava) belongs to the family Myrtaceae, is a most important medicinal plant used in folk medicine to treat gastrointestinal, respiratory disturbances and used as anti-inflammatory medicine. The present study was carried out to evaluate the antioxidant, antimicrobial and cytotoxicity capacities of various crude extracts of the leaves of guava. Dried plant material macerated in ethanol gave crude extract that was Kupchan’s partitioned into hexane, chloroform, and ethyl acetate fractions. The cytotoxicity activity was carried out by brine shrimp lethality bioassay and antimicrobial activity was determined by agar disc diffusion method against E. coli, P. aeruginosa and S. aurues using four different concentrations of each extract including 250, 500, 1000, and2000μg/ml. Cytotoxicity was estimated using brine shrimp test. 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay was used for radical scavenging analysis. All extracts did not show any cytotoxicity or antibacterial activity at any of the tested concentration but all extracts showed potent radical scavenging activity, the highest is seen with the hydro-alcoholic and ethyl acetate extracts.

 To read more... Fulltext in Global Journal of Pharmacy & Pharmaceutical Sciences in Juniper Publishers

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