Formulation and Evaluation of Solid Dispersion of Glimepiride in to Sustained Release-Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences


Authored by Anusha Pagadala

A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers.

Comments

Post a Comment

Popular posts from this blog

An Overview of Neptunia prostrata: A Source of Herbal Medicine of Ethnopharmacological Importance - Juniper Publishers

Image
  JUNIPER PUBLISHERS - GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES   Authored by Acharya PC Introduction Plants are used in the treatment of various diseases from the ancient time. The use of plants as a source of medicine lies deep in the root of antiquity. The traditional Indian system of medicine, Ayurveda and Unani are based on the use of plants, animals and other natural substances. The history of medicinal plants dates back to Rigveda, perhaps the oldest repository of human knowledge, which was written in about 4500-1600 B.C and Ayurveda (about 2500 B.C) which provide the detail accounts of many herbal drugs [ 1 ]. Most of the medicinally active substances investigated in the 19th and 20th centuries used in the form of crude extract [ 2 , 3 ]. Medicinal plants and natural product derived medicines are widely used in traditional cultures all over the world and they are becoming increasingly popular in modern society as natural alternatives to synthetic me
Read more

Formulation and Evaluation of Chronomodulated Drug Delivery of Montelukast Sodium--Juniper Publishers

Image
JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES An oral press coated tablet containing Montelukast sodium was formulated with an outer barrier layer of different compositions of hydrophobic polymer eythyl cellulose and hydrophilic polymer hydroxyl propyl methyl cellulose. This press coated tablet was prepared by using direct compression and wet granulation methods in order to achieve the predetermined lag time. Keywords: Pulsatile drug delivery systems (PDDS); Nocturnal asthma(NA); Chronopharmacology; Circadium Rhythms; Burst release; Lag time Abbreviations: EC: Ethyl Cellulose; HPMC: Hydroxy Propyl Methyl Cellulose; FTIR: Fourier Transform Infra Red; SLS: Sodium Lauryl Sulphate; IR: Immediate Release; ChrDDS: Chrono Modulated Drug Delivery Systems; PCT: Press Coated Tablets Introduction Controlled drug delivery systems [1] have acquired a centre stage in the area of pharmaceutical R &D sector. Such systems offe
Read more

Infection Control in Labor and Delivery Room, Learning from the Small Hospital Based Project-Juniper Publishers

Image
JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Background: It has been estimated that around 36% of the neonatal deaths occur due to infection in the lower and middle income countries. Infection control is a more substantial area of concern, particularly in Labor and delivery room. Multiple factors can cause infection in the labor room, therefore it is important to assess various factors of maternal and neonatal infection. Hence we explored multiple factors through this project and developed the action plan to address those factors effectively. Methods: During our Leadership and Management course, we conducted a project in Labor room pertaining to a prevalent issue. The whole process from identification of the issue to the resolution was supposed to be in the light of leadership and management concepts. After a thorough analysis and discussion, an action plan was formulated considering the resources, audience, facilitie
Read more