Salivary Nitrite in Patients with Type 2 Diabetes Mellitus: Role of Diabetic Pharmacotherapy-Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences


Authored by Hayder M Alkuraishy

Salivary nitrite is derived from salivary nitrate that obtained from ingested nitrate since 25% of nitrate is secreted through saliva thus; salivary nitrate is 10-20 times higher than plasma nitrate. Nitrate-nitric-NO pathway plays a role in prevention of insulin resistance and progression of diabetes mellitus. Because of salivary nitrite is also generated from NO metabolism therefore, salivary nitrite may reflect the endogenous NO production and endothelial function in various diseases thus; the aim of present study was evaluation of salivary nitrite in controlled and complicated T2DM regarding the current diabetic pharmacotherapy. In this study a total number of 50 patients with T2DM were selected randomly compared with 27 healthy subjects. 10ml of venous blood from all patients and healthy subjects after an overnight fasting was drawn, lipid profile, fasting blood glucose, plasma nitrate, plasma nitrite, nitric oxide NO and salivary nitrite were determined in patients with T2DM regarding specific diabetic pharmacotherapy and complications compared to healthy control. Salivary nitrite was high in patient with complications p=0.04 compared with control and near normal in diabetic patient without complications. Metformin increases salivary nitrite more than glimepiride but combination of metformin plus glimepiride produced significant amelioration in salivary nitrite levels.

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