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Effect of Vitamin E on the Anti-Coagulant Response-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Fluindione is the most used Vitamin K antagonists in France. It has been sparsely studied and few interactions have been reported with food sources. This case reveals a significant rise in INR when fluindione was associated to fatty acid (palmitic/oleic/linoleic acid 2g/day) or vitamin E (1g/day). Presentation of Case: A 80-year-old male (weight 74 kg, body surface area 1.91 m²) with a history of severe allergic drug eruption documented with low molecular weight heparins, vancomycin, rifamycin and netromycin was treated and stabilized (International Normalized Ratio (INR) = 3.5) with fluindione (10 to 15 mg once per day) for cardiovascular risks due to a mechanical aortic heart valve and an aortic tube. During hospitalization, the patient stopped eating dietary supplements containing fatty acids and vitamin E (Day 0), and then, presented an imbalance of the INR (Day 2: INR =...
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Comparison of Morphological Analysis of RBC through Peripheral Smear and Automated Method-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Aim: To compare the morphology of red blood cells by peripheral smear and automated method. Objective: Comparison of morphology of red blood cells by using peripheral smear and automated method. Background: Counting of red blood cells (RBC) in blood cell images is very important to detect as well as to follow the process of treatment of many diseases like anaemia, leukaemia etc. However, locating, identifying and counting of -red blood cells manually are tedious and timeconsuming that could be simplified by means of automatic analysis. Reason: To know which is the most effective method of analysing morphology of RBC. Keywords: Red blood cells; Observers; Automated method Introduction Red blood cells (RBCs), also known as erythrocytes, are the most common type of blood cells in our body and it is the principal means of delivering ...
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Formulation and Evaluation of Solid Dispersion of Glimepiride into Sustained Release-Juniper Publishers

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JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers. Keywords: Solid dispersion, Diabetes mellitus, Sustained drug release Abbreviations: PVP: Poly Vinyl Pyrrolidone; HPMC: Hydroxy Propyl Methyl Cellulose; FTIR: Fourier Transform Infra Red; MCC: Micro Crystalline Cellulose Introduction The objective of sustained release [1] dosage form i...
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