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Genotoxicity: Mechanisms, Testing Guidelines and Methods
JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Authored by Rajendra SV Abstract Genotoxicity is one of the major causes for cancer. Genotoxins are agents that can cause the damage of DNA or chromosomal structure thereby causing mutations. It can be chemical or radiation. This damage in the somatic cells will lead to various diseases ranging to cancer whereas the damage to the germ cell will lead to heritable diseases. Better identification and understanding of genotoxins would enable us to prevent the potential damage that can be caused by these genotoxic agents. In this article we discuss about the basic of genotoxicity and the importance of genotoxic studies. Keywords: Genotoxins, Mutagens, DNA Damage, Chromosomal mutation, Testing guidelines. Go to Introduction Genotoxicity is a word used in genetics that describes the possession of substance that has destructive effect on the genetic material of the cell (DNA, RNA) thus aff...
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Juniper Publishers | LinkedIn Juniper Publishers To advance the creation, communication and application of scientific knowledge to benefit society and improve people’s lives. The prime mission of juniper is to make continuous efforts in transforming the scientific information from people around the world by publishing in our website. Our vision is to build an open science platform where everybody has equal opportunity to seek, share and generate knowledge, and that empowers researchers in their daily work. Juniper publishers are established with the main motto of spreading the scientific information to the whole research community throughout the universe. We as an Open Access publishers are on the way to reach the peaks of the provision in scientific publications through on-line. With Open Access process, we take away all the barriers that ancient publication models had. To match with the rapidity of the twenty first century, and thus to stand as a large international analy...
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