Juniper Publishers- Journal of Pharmacy Pharmaceutical Sciences

JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Gene therapy is the therapy where nucleic acid polymers are used to delivery into patient’s cell as a drug to treat the disease and using an adenovirus vector which is insert the new gene into cell and this gene make a functional protein to treat or control of the disease and it is also used to treat the cancer or hormonal diseases [1,2]. On the other hand, stem cell therapy is the therapeutic delivery of stem cell into patient’s body to treat or prevent of the disease or condition such as blood stem cell used to treat the blood diseases and it is also known as regenerative medicine [3,4]. Stem cell grow in a lab and manipulated of specialize cell into specific types cell such as heart muscle cells,blood cells,nerve cells [4,5]. In case of defective or injured heart muscle cell,stem cell contributes to repairing defective or injured heart muscle cells [6,7] Non biological drug

JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers. Keywords: Solid dispersion, Diabetes mellitus, Sustained drug release Abbreviations: PVP: Poly Vinyl Pyrrolidone; HPMC: Hydroxy Propyl Methyl Cellulose; FTIR: Fourier Transform Infra Red; MCC: Micro Crystalline Cellulose Introduction The objective of sustained release [1] dosage form i

JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES A simple, precise, specific, sensitive and accurate stability indicating RP-HPLC method for determination of secnidazole and its degradation products in tablets. The separation was performed on teknokroma, tracer excel C18 column (25cm x 0.46cm.5μm) using mobile phase consisting of water: methanol: acetonitrile in ratio (73: 17: 10). A flow rate was set at 1mL/min; the detection wavelength was set at 228nm. The calibration curves were found to be linear in the concentration range of 50-150/mL (r2 =0.9997) and 0.25-7.5μg/mL (r2 =0.998) at assay level and low-level of secnidazole. The percentage recoveries of secnidazole were 100.76-101.66% and 97.87-102% at assay and low-level, respectively at 95% confidence limit. The intraday precision was 0.553% and 1.35% at assay level and low-level, respectively. The intermediate precision was 0.56% and 3.10% at assay level and low-level, respectively.