Future Medicine such as Gene or Stem Cell Therapy are Better than Nonbiological or Some Biological (Antibiotic) Medicine-Juniper Publishers
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Gene therapy is the therapy where nucleic acid
polymers are used to delivery into patient’s cell as a drug to treat the
disease and using an adenovirus vector which is insert the new gene
into cell and this gene make a functional protein to treat or control of
the disease and it is also used to treat the cancer or hormonal
diseases [1,2]. On the other hand, stem cell therapy is the therapeutic
delivery of stem cell into patient’s body to treat or prevent of the
disease or condition such as blood stem cell used to treat the blood
diseases and it is also known as regenerative medicine [3,4]. Stem cell
grow in a lab and manipulated of specialize cell into specific types
cell such as heart muscle cells,blood cells,nerve cells [4,5]. In case
of defective or injured heart muscle cell,stem cell contributes to
repairing defective or injured heart muscle cells [6,7]
Non biological drug are chemical substance which
obtained by chemical synthesis processes and their structure is known
and it is used to treatment of diseases,cure of disease,control of
diseases.non biological drugs such as
losartan,metformin,atenolol,propranolol,paracetamol,ranitidine atropine
etc bind with receptor or enzyme and stimulate or inhibit the receptor
or enzyme and give desire action [8-10]. On the other hand, antibiotic
(biological drug) are chemical substance which obtain from biological
sources such as differents microorganism [11,12]. Antibiotic such as
penicillin,cephalosporin are used to growth inhibit or kill of the
microorganism but at present,antibiotic are resistance by microorganism
and Non biological drug gradually decrease their efficacy and so in
future gene therapy and stem cell therapy are more dependable than
antibiotic or Non biological drug [1,3,4,9,10,13,14].
Method
For the purpose of research work, 20 specimens are divided into 2 groups. 1st group for Non biological drug study and contain
10 specimens (patient’s) and 2nd group for biological (antibiotic) drug study and contain 10 specimens.
Non Biological Drug Study
1st group (Non biological drug) are sub
divided into 3 group such as A,B,C group.A group contained 3 specimen
(patient’s) and patient’s had hypertention disease and applied
antihypertensive drug such as losartan, bisoprolol; B group contained 3
specimen(patient’s) and patient’s had diadetes disease and applied
antidiabetes drug such as metformin,glibenclamide; C group contained 4
specimen (patient’s) and patient’s had asthma disease and applied
antiasthmatic drug such as theophylline,inhaler. 1st group had been monitoring for 4 years and recorded their dose requirement and disease condition (Table 1).
Biology (Antibiotic) Drug Study
2nd group is subdivided into 5 groups such as A, B, C, D,
E. This 5 subdivided group sample was sent to the different
diagnostic center for culture test (antibiotic resistance test).
A group had 2 specimens (A1,A2). A1, A2 urine sample (due to
UIT symptom show) was sent to modern diagnostic centre Ltd
(Dhaka, Bangladesh), B group had 2 specimen(B1,B2).B1,B2
urine sample(due to UIT symptom show) was sent to meghna
laboratory (Chittagong, Bangladesh), C group had 2 specimen
(C1,C2). C1, C2 sputum sample (due to RTI symptom show) was
sent to chevron diagnostic centreLmd (Chittagong,Bangladesh),
D group had 2 specimen (D1, D2). D1, D2 blood sample (due to
several surgical wound infection) was sent to sigma laboratory
Ltd (Chittagong, Bangladesh), E group had 2 specimen (E1,E2).
E1, E2 blood sample (due to high fever, stomach pain) was sent to
CSCR diagnostic centre Ltd (chittagong, Bangladesh) and report
was collected and recorded (Table 2).
Result
Non biological drug study
Biology (antibiotic) drug study
The study of the result shows that the drugs both some
biological (only antibiotic or antimicrobial agent) and Non
biological drug are gradually decrease their efficacy. Biological
drug such as antimicrobial agent,antibiotic are gradually
resistance by microorganism. After 20 to 40 years later 60 to
90 percent antibiotic or antimicrobial agent will be resistance
by microorganism. Non biological drug could not bind properly
with their specific receptor due to structural change of receptor
or decrease the affinity of drug to receptor. After 30 to 40 years
later the drug efficacy gradually decrease at low level and show
low therapeutic effect. At this time the innovative treatment
such as gene therapy,stem cell therapy are the more dependable
treatment for control or prevent or cure of the diseases. Specific
gene therapy used for specific disease control or cure.Manipulation
of gene in the human cell and produce protective agent such as
protein, antibody, enzyme) which inhibit the growth or kill of
the microorganism and also control the hormonal diseases and
cellular function and this protective agent such as protein which
bind with receptor (structural change receptor which could not
bind with Nonbiological drug) and give the desire function. On the
other hand,stem cell therapy which control the all abnormal cell
such as cancer cell,hormonal abnormal cell etc. and prevent the
diseases and give the desires cellular function.
Discussion
Nonbiological drug are synthetic compounds which could
not derived from living organism and which bind with receptor,
enzyme and show their desire action [9,10]. The long time use
of Nonbiological drug are gradually decrease their efficacy due
to decrease the affinity of drug to receptor or structural change
of the receptor and drug could not properly bind with receptor
or enzyme and could not show their therapeutic effect [8,10,15].
The dose of the drug are gradually increasing day by day, at a
certain time the drug could not work properly and does not give
their therapeutic effect and do not improve the disease condition
[8,10,17]. Antibiotic resistance is the ability of microorganism to
stop the action of antibiotic and increase the difficulty to treat
the infectious diseases [12,15]. Antibiotic resistance due to the
genetic mutation of microorganism,resistance gene transfer one
microorganism to another microorganism, misuse of antibiotic,
production of enzyme by microorganism [11,18].
Antibiotic resistance is increasing day by day such as
staphylococcus aureus resistant the methicillin, penicillin,
Cloxacillin, erythromycin, tetracycline, vancomycin and
streptococcus pyogene resistant the tetracycline, erythromycin,
clindamycin, vancomycin, chloramphenicol and Esch. Coli
resistant the amoxicillin, cephalexin, ciprofloxacin, nalidixic acid,
cephradin, cotrimoxazole and coliform bacteria resistant the tetracyclin, ampicillin, azithromycin, doxycycline, gentamycin
and salmonella typhi resistant the chloramphenicol, ampicillin,
ciprofloxacin, tetracyclin, vancomycin, amoxicillin, cephalexin,
cephradin.after 20-30 year later 50-70 percent antibiotic will
be resistance and 40-50 year later 70-90 percent antibiotic will
be resistance and many people die due to infectious diseases
[11,12,14,19].
Gene therapy is the manipulation of the gene into the cell and
gives the desired functional protein (enzyme,antibody, hormone)
which control or prevent the diseases such as manipulation of
tumor suppression gene, which control the tumor or cancer
diseases,manipulation of antibody producing gene, which inhibit
the growth or kill the microorganisms [1,13,20]. Manipulation of
gene can also control all genetic diseases and strong the immune
system and control all hormonal diseases [1,2].
Stem cell have the ability of regeneration of cell such as
regeneration of brain cell for the treatment of Parkinson’s diseases,
Alzheimer’s diseases and other brain diseases. Blood stem cell can
regeneration of blood cell for the treatment of blood cancer cell
[3,4]. Diabetes patient’s could not produce insulin due to the lack
of function of insulin producing beta cell and by stem cell therapy,
beta cell can be regeneration and produce insulin and control the
diabetes disease [6,7]. Stem cell may be advance in future and
control the cellular problem and other diseases [4,5]. The findings
of the study showed that day by day nonbiological drug efficacy
are gradually decrease and amount of dose gradually increase
[8,10]. At a certain time,Non biological drug could not work in
our body and could not give the desire therapeutic action [15,16].
On the hand,day by day antibiotic resistant are gradually increase
[12,14]. At a certain time,antibiotic could not work in our body
and could not kill the microorganism and many people dies due to
infectious diseases [11,12]. At this time,the innovative treatment
such as gene therapy or stem cell therapy are most dependable
treatment for the prevent or control of the diseases condition and
safe the life of the people [1,3,4,13].
Conclusion
In future non biological drug could not work properly in our
body and antibiotic resistance may be 70-90 percent(30-50 year
later) and many people dies due to diseases could not improve
[8,14,16]. At this time the innovative treatment such as gene
therapy or stem cell therapy are most dependable treatment for
the treatment of diseases condition [1,6,7].
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