Juniper Publishers- Journal of Pharmacy Pharmaceutical Sciences

  JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Authored by  Rajendra SV Abstract Genotoxicity is one of the major causes for cancer. Genotoxins are agents that can cause the damage of DNA or chromosomal structure thereby causing mutations. It can be chemical or radiation. This damage in the somatic cells will lead to various diseases ranging to cancer whereas the damage to the germ cell will lead to heritable diseases. Better identification and understanding of genotoxins would enable us to prevent the potential damage that can be caused by these genotoxic agents. In this article we discuss about the basic of genotoxicity and the importance of genotoxic studies. Keywords:  Genotoxins, Mutagens, DNA Damage, Chromosomal mutation, Testing guidelines. Go to Introduction Genotoxicity is a word used in genetics that describes the possession of substance that has destructive effect on the genetic material of the cell (DNA, RNA) thus aff...

JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Ascites is a frequent complication of cirrhosis that accounts for over 75% of episodes of ascites. Patients with cirrhotic ascites have marked splanchnic vasodilation and arterial hypotension with subsequent activation of vasoconstrictive and anti-natriuretic mechanisms. One of the most serious complications in cirrhotic patients with ascites is the occurrence of refractoriness that is the inability to resolve ascites by the standard medical treatment. The aim of this study is to evaluate the effects of etilefrine on systemic hemodynamics, renal function and control of ascites in chronic hepatitis C (CHC) patients with cirrhotic refractory ascites receiving standard medical treatment (SMT) with low sodium diet and maximal diuretic doses of 160mg/day of furosemide and 400mg/day of spironolactone. Methods: A total of 50 CHC patients with cirrhotic refractory ascites were prospe...

JUNIPER PUBLISHERS-OPEN ACCESS GLOBAL JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES Aim: To compare the morphology of red blood cells by peripheral smear and automated method. Objective: Comparison of morphology of red blood cells by using peripheral smear and automated method. Background: Counting of red blood cells (RBC) in blood cell images is very important to detect as well as to follow the process of treatment of many diseases like anaemia, leukaemia etc. However, locating, identifying and counting of -red blood cells manually are tedious and timeconsuming that could be simplified by means of automatic analysis. Reason: To know which is the most effective method of analysing morphology of RBC. Keywords: Red blood cells; Observers; Automated method Introduction Red blood cells (RBCs), also known as erythrocytes, are the most common type of blood cells in our body and it is the principal means of delivering ...