Juniper Publishers- Journal of Pharmacy Pharmaceutical Sciences

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Afaf M Weli Psidium guajava (guava) belongs to the family Myrtaceae, is a most important medicinal plant used in folk medicine to treat gastrointestinal, respiratory disturbances and used as anti-inflammatory medicine. The present study was carried out to evaluate the antioxidant, antimicrobial and cytotoxicity capacities of various crude extracts of the leaves of guava. Dried plant material macerated in ethanol gave crude extract that was Kupchan’s partitioned into hexane, chloroform, and ethyl acetate fractions. The cytotoxicity activity was carried out by brine shrimp lethality bioassay and antimicrobial activity was determined by agar disc diffusion method against E. coli, P. aeruginosa and S. aurues using four different concentrations of each extract including 250, 500, 1000, and2000μg/ml. Cytotoxicity was estimated using brine shrimp test. 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) as

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Sumera Aziz Ali Ozone in the stratosphere is very important as it acts as a safeguard for the earth and protects life from harmful ultraviolet radiations coming from the sun. Depletion of stratospheric ozone, resulting from atmospheric pollution has led to increased ultraviolet radiation at the earth’s surface as well as spectral shifts to the more biologically damaging shorter wavelengths. A decrease in the concentration of stratospheric ozone enhances the solar ultraviolet (UV) radiation, which is harmful to the growth of the plant and various other metabolic processes of the organisms and might cause changes in pigment concentrations, nucleic acids, and proteins. Multiple causes of ozone depletion have been identified in the literature review, but the findings are not synthesized at one place. Thus, the purpose of this paper was to review the causes of ozone depletion and to propo

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Sumera Ali Background:  It has been estimated that around 36% of the neonatal deaths occur due to infection in the lower and middle income countries. Infection control is a more substantial area of concern, particularly in Labor and delivery room. Multiple factors can cause infection in the labor room, therefore it is important to assess various factors of maternal and neonatal infection. Hence we explored multiple factors through this project and developed the action plan to address those factors effectively. To read more... FullText in  Global Journal of Pharmacy & Pharmaceutical Sciences in Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Ikram Hasan Gene therapy is the therapy where nucleic acid polymers are used to delivery into patient’s cell as a drug to treat the disease and using an adenovirus vector which is insert the new gene into cell and this gene make a functional protein to treat or control of the disease and it is also used to treat the cancer or hormonal diseases [1,2]. On the other hand, stem cell therapy is the therapeutic delivery of stem cell into patient’s body to treat or prevent of the disease or condition such as blood stem cell used to treat the blood diseases and it is also known as regenerative medicine [3,4]. Stem cell grow in a lab and manipulated of specialize cell into specific types cell such as heart muscle cells,blood cells,nerve cells [4,5]. In case of defective or injured heart muscle cell,stem cell contributes to repairing defective or injured heart muscle cells. To read more..

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Anusha Pagadala A sustained release tablet containing Glimepiride was formulated by using solid dispersion technique. Solid dispersions of glimepiride were prepared by using Urea and PEG 6000 as carrier in drug: carrier 1:1, 1:2, 1:3, 1:4 ratios by Fusion method. From these all solid dispersions formulation SDUF3 containing Urea shows better dissolution compared to other solid dispersions. This optimized solid dispersion is formulated into sustained release tablets by direct compression method using hydroxy propyl methyl cellulose and Ethyl cellulose polymers. To read more... FullText in  Global Journal of Pharmacy & Pharmaceutical Sciences in Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Ali Abdo Saif Ahmed Algaradi A simple, precise, specific, sensitive and accurate stability indicating RP-HPLC method for determination of secnidazole and its degradation products in tablets. The separation was performed on teknokroma, tracer excel C18 column (25cm x 0.46cm.5μm) using mobile phase consisting of water: methanol: acetonitrile in ratio (73: 17: 10). A flow rate was set at 1mL/min; the detection wavelength was set at 228nm. The calibration curves were found to be linear in the concentration range of 50-150/mL (r2 =0.9997) and 0.25-7.5μg/mL (r2 =0.998) at assay level and low-level of secnidazole. The percentage recoveries of secnidazole were 100.76-101.66% and 97.87-102% at assay and low-level, respectively at 95% confidence limit. The intraday precision was 0.553% and 1.35% at assay level and low-level, respectively. The intermediate precision was 0.56% and 3.10% at assa

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Madhuri Asiniparthi An oral press coated tablet containing Montelukast sodium was formulated with an outer barrier layer of different compositions of hydrophobic polymer eythyl cellulose and hydrophilic polymer hydroxyl propyl methyl cellulose. This press coated tablet was prepared by using direct compression and wet granulation methods in order to achieve the predetermined lag time. To read more.. PHP  in  Global Journal of Pharmacy & Pharmaceutical Sciences  in Juniper Publishers