Development and Validation of UV Spectrophotom- etric Method for Simultaneous Estimation of Omeprazole and Domperidone in Capsule Dosage forms-Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences


Authored by Prasanthi T

A simple, precise, rapid and accurate UV Spectrophotometric method has been developed and validated for the simultaneous estimation of Omeprazole (OMP) and Domperidone (DOM) in combined pharmaceutical dosage forms. The method was developed by using methanol as a solvent. Omeprazole exhibits absorption maximum at 301 nm and Domperidone shows absorption maximum at 287.2 nm in methanol. The developed method was obeyed Beer Lambert’s law in the concentration range of 2-12 μg/mL for both OMP and DOM. The accuracy of method was confirmed by recovery studies from capsules at three different levels of standard additions. %RSD values below 2 for intra-day and inter-day precision indicates that the proposed method is highly reproducible. The results of study demonstrated that the proposed method can be applied to formulation and for routine analysis.


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