Juniper Publishers- Journal of Pharmacy Pharmaceutical Sciences

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Prasanthi T A simple, precise, rapid and accurate UV Spectrophotometric method has been developed and validated for the simultaneous estimation of Omeprazole (OMP) and Domperidone (DOM) in combined pharmaceutical dosage forms. The method was developed by using methanol as a solvent. Omeprazole exhibits absorption maximum at 301 nm and Domperidone shows absorption maximum at 287.2 nm in methanol. The developed method was obeyed Beer Lambert’s law in the concentration range of 2-12 μg/mL for both OMP and DOM. The accuracy of method was confirmed by recovery studies from capsules at three different levels of standard additions. %RSD values below 2 for intra-day and inter-day precision indicates that the proposed method is highly reproducible. The results of study demonstrated that the proposed method can be applied to formulation and for routine analysis. To view more......

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Ranasinghe RLDS Macrotyloma uniflorum  (Lam.) Verdc commonly known as horse gram is a kind of legume of tropics and subtropics. Its medicinal uses are known to Ayurveda and Sri Lankan traditional physicians for centuries. Present study was undertaken to collect data on medicinal uses and nutritional values of  M. uniflorum . Ayurveda pharmacodynamic properties of  M. uniflorum  are  Kashaya Rasa, Laghu, Ruksha, Tikshna Guna, Ushna Veerya and Katu Vipaka.  Various medicinal preparations such as Dhanyamla and decoctions are prepared using seeds of  M. uniflorum.  It is mainly used as a tonic, astringent, diuretic and also recommended in rheumatism, neuralgia and other several diseases. Horse gram seeds are rich in natural phenols; mostly phenolic acids, flavonoids and the major anti-oxidants. Horse gram is considered as animal fodder a...

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Hayder M Alkuraishy Salivary nitrite is derived from salivary nitrate that obtained from ingested nitrate since 25% of nitrate is secreted through saliva thus; salivary nitrate is 10-20 times higher than plasma nitrate. Nitrate-nitric-NO pathway plays a role in prevention of insulin resistance and progression of diabetes mellitus. Because of salivary nitrite is also generated from NO metabolism therefore, salivary nitrite may reflect the endogenous NO production and endothelial function in various diseases thus; the aim of present study was evaluation of salivary nitrite in controlled and complicated T2DM regarding the current diabetic pharmacotherapy. In this study a total number of 50 patients with T2DM were selected randomly compared with 27 healthy subjects. 10ml of venous blood from all patients and healthy subjects after an overnight fasting was drawn, lipid profile,...

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Afaf M Weli Psidium guajava (guava) belongs to the family Myrtaceae, is a most important medicinal plant used in folk medicine to treat gastrointestinal, respiratory disturbances and used as anti-inflammatory medicine. The present study was carried out to evaluate the antioxidant, antimicrobial and cytotoxicity capacities of various crude extracts of the leaves of guava. Dried plant material macerated in ethanol gave crude extract that was Kupchan’s partitioned into hexane, chloroform, and ethyl acetate fractions. The cytotoxicity activity was carried out by brine shrimp lethality bioassay and antimicrobial activity was determined by agar disc diffusion method against E. coli, P. aeruginosa and S. aurues using four different concentrations of each extract including 250, 500, 1000, and2000μg/ml. Cytotoxicity was estimated using brine shrimp test. 2, 2-Diphenyl-1-picrylhydrazyl ...

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Sumera Aziz Ali Ozone in the stratosphere is very important as it acts as a safeguard for the earth and protects life from harmful ultraviolet radiations coming from the sun. Depletion of stratospheric ozone, resulting from atmospheric pollution has led to increased ultraviolet radiation at the earth’s surface as well as spectral shifts to the more biologically damaging shorter wavelengths. A decrease in the concentration of stratospheric ozone enhances the solar ultraviolet (UV) radiation, which is harmful to the growth of the plant and various other metabolic processes of the organisms and might cause changes in pigment concentrations, nucleic acids, and proteins. Multiple causes of ozone depletion have been identified in the literature review, but the findings are not synthesized at one place. Thus, the purpose of this paper was to review the causes of ozone depletion and...

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Sumera Ali Background:  It has been estimated that around 36% of the neonatal deaths occur due to infection in the lower and middle income countries. Infection control is a more substantial area of concern, particularly in Labor and delivery room. Multiple factors can cause infection in the labor room, therefore it is important to assess various factors of maternal and neonatal infection. Hence we explored multiple factors through this project and developed the action plan to address those factors effectively. To read more... FullText in  Global Journal of Pharmacy & Pharmaceutical Sciences in Juniper Publishers

Juniper Publishers-Open Access Journal of Pharmacy & Pharmaceutical Sciences Authored by  Ikram Hasan Gene therapy is the therapy where nucleic acid polymers are used to delivery into patient’s cell as a drug to treat the disease and using an adenovirus vector which is insert the new gene into cell and this gene make a functional protein to treat or control of the disease and it is also used to treat the cancer or hormonal diseases [1,2]. On the other hand, stem cell therapy is the therapeutic delivery of stem cell into patient’s body to treat or prevent of the disease or condition such as blood stem cell used to treat the blood diseases and it is also known as regenerative medicine [3,4]. Stem cell grow in a lab and manipulated of specialize cell into specific types cell such as heart muscle cells,blood cells,nerve cells [4,5]. In case of defective or injured heart muscle cell,stem cell contributes to repairing defective or injured heart muscle cells. To re...